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Article

The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.

The Journal of biological chemistry - 2 Nov 2012

Brugarolas Pedro, Movahedzadeh Farahnaz, Wang Yuehong, Zhang Nan, Bartek Iona L, Gao Yihe N, Voskuil Martin I, Franzblau Scott G, He Chuan

Abstract excerpt

Mycobacterium tuberculosis thrives in oxidative environments such as the macrophage. To survive, the bacterium must sense and adapt to the oxidative conditions. Several antioxidant defenses including a thick cell wall, millimolar concentrations of small molecule thiols, and protective enzymes are known to help the bacterium withstand the oxidative stress. However, oxidation-sensing regulators that control these...

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Identifiers

PMID: 22992749
DOI: 10.1074/jbc.M112.388611
PMCID: PMC3488046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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