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Article

Generation and characterization of a conditional allele of Interferon Regulatory Factor 6.

Genesis (New York, N.Y. : 2000) - 1 Jul 2017

Smith Arianna L, Kousa Youssef A, Kinoshita Akira, Fodor Kate, Yang Baoli, Schutte Brian C

Abstract excerpt

Interferon Regulatory Factor 6 (IRF6) is a critical regulator of differentiation, proliferation, and migration of keratinocytes. Mutations in IRF6 cause two autosomal dominant disorders characterized by cleft lip with or without cleft palate. In addition, DNA variation in IRF6 confers significant risk for non-syndromic cleft lip and palate. IRF6 is also implicated in adult onset development and disease processes,...

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Identifiers

PMID: 28481036
DOI: 10.1002/dvg.23038
PMCID: PMC5509482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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