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Article

Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma

1 May 2017

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5-year survival of 8%. Current therapeutic regimens are largely ineffective and underscore the need for novel treatment strategies. Chromosomal rearrangements involving the anaplastic lymphoma kinase (ALK) gene have been identified in several neoplasms. In addition, ALK protein inhibitors have proven efficacy in patients with...

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Identifiers

PMID: 28476735
DOI: 10.6004/jnccn.2017.0058

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