Article
An Oncogenic ALK Fusion and an RRAS Mutation in KRAS Mutation-Negative Pancreatic Ductal Adenocarcinoma.
The oncologist - 1 Feb 2017
Shimada Yoko, Kohno Takashi, Ueno Hideki, Ino Yoshinori, Hayashi Hideyuki, Nakaoku Takashi, Sakamoto Yasunari, Kondo Shunsuke, Morizane Chigusa, Shimada Kazuaki, Okusaka Takuji, Hiraoka Nobuyoshi
Abstract excerpt
PURPOSE: Oncogenic mutations in the KRAS gene are a well-known driver event, occurring in >95% of pancreatic cancers. The objective of this study was to identify driver oncogene aberrations in pancreatic cancers without the KRAS mutation. METHODS: Whole-exome and transcriptome sequencing was performed on four cases of KRAS mutation-negative pancreatic ductal adenocarcinoma, which were identified in a cohort of...
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