Article
Molecular characterisation of pancreatic ductal adenocarcinoma with NTRK fusions and review of the literature.
Journal of clinical pathology - 1 Mar 2023
Allen Michael J, Zhang Amy, Bavi Prashant, Kim Jaeseung C, Jang Gun Ho, Kelly Deirdre, Perera Sheron, Denroche Rob E, Notta Faiyaz, Wilson Julie M, Dodd Anna, Ramotar Stephanie, Hutchinson Shawn, Fischer Sandra E, Grant Robert C, Gallinger Steven, Knox Jennifer J, O'Kane Grainne M
Abstract excerpt
AIMS: The majority of pancreatic ductal adenocarcinomas (PDACs) harbour oncogenic mutations in KRAS with variants in TP53, CDKN2A and SMAD4 also prevalent. The presence of oncogenic fusions including NTRK fusions are rare but important to identify. Here we ascertain the prevalence of NTRK fusions and document their genomic characteristics in a large series of PDAC. METHODS: Whole genome sequencing and RNAseq were...
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