Article

Targeted Sequencing of Pancreatic Ductal Adenocarcinoma Tissue

2023-01-17

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer and the majority of patients present with metastatic disease. Metastatic spread requires a reorganisation of the actin cytoskeleton, a process that is dependent on the Rho family GTPases and their interaction with subsequent downstream effectors. The p21 activated kinases (also known as the PAKs) are effectors of Rho GTPases Cdc42 and Rac and play key...

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Literature Corpus work: 48fa3c5a-4840-5bad-93f9-e319ddd9a47d
DOI: 10.1101/2023.01.13.523431

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