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Fusion genes in pancreatic tumors

19 Feb 2024

Abstract excerpt

Gene fusions and rearrangements play a crucial role in tumor biology. They are rare events typically detected in KRAS wild-type (WT) pancreatic tumors. Their identification can inform clinical management by enabling precision oncology, as fusions involving BRAF, FGFR2, RET, NTRK, NRG1, and ALK represent actionable targets in KRAS-WT cancers, and serve diagnostic purposes since fusions involving PRKACA/B represent...

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PMID: 38378317
DOI: 10.1016/j.trecan.2024.01.009

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