Article
CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts.
Scientific reports - 25 Feb 2016
Yuan Lin, Sui Tingting, Chen Mao, Deng Jichao, Huang Yongye, Zeng Jian, Lv Qingyan, Song Yuning, Li Zhanjun, Lai Liangxue
Abstract excerpt
Cataracts are the leading cause of vision loss in the world, although surgical treatment can restore vision in cataract patients. Until now, there have been no adequate animal models for in vivo studies of artificial lens safety and drug interactions. Genetic studies have demonstrated that GJA8 is involved in maintaining lens opacity and proper lens development. In this study, a cataract model with GJA8 gene...
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