Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2017

McRobb Lucinda S, McGrath Kristine C Y, Tsatralis Tania, Liong Eleanore C, Tan Joanne T M, Hughes Gillian, Handelsman David J, Heather Alison K

Abstract excerpt

OBJECTIVE: Vascular calcification is associated with increased risk of myocardial infarction and stroke. The objective of this work was to examine the ability of 17β-estradiol (E2) to stimulate calcification of vascular smooth muscle cells (VSMC) in vivo, using aged apolipoprotein E-null mice with advanced atherosclerotic lesions, and subsequently to explore underlying mechanisms in vitro. APPROACH AND RESULTS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estradiol
Share to Estrogen Receptor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neointima

Share to Osteocalcin

Share to Osteogenesis

Share to Osteopontin

Share to Plaque, Atherosclerotic

Share to Vascular Calcification

Source

Identifiers

PMID: 28473445
DOI: 10.1161/ATVBAHA.117.309054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation.PMID 28473445Read ↗

The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.Semantic proximity Read ↗

Increased calcification in osteoprotegerin-deficient smooth muscle cells: Dependence on receptor activator of NF-κB ligand and interleukin 6.Semantic proximity Read ↗

Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaqueSemantic proximity Read ↗

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.Semantic proximity Read ↗

Differential effects of 17beta-estradiol and raloxifene on VSMC phenotype and expression of osteoblast-associated proteins.Semantic proximity Read ↗

Phosphatidic Acid Mediated Sonodynamic Therapy Facilitates M1 Macrophage Osteoclastic Function and Alleviates Early Vascular CalcificationSemantic proximity Read ↗

The molecular biology and pathophysiology of vascular calcification.Semantic proximity Read ↗

Wnt Signaling in Vascular CalcificationSemantic proximity Read ↗

Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice.Semantic proximity Read ↗

Plaque Calcification During Atherosclerosis Progression and Regression.Semantic proximity Read ↗

Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification.Semantic proximity Read ↗

Lyso-phosphatidylcholine induces osteogenic gene expression and phenotype in vascular smooth muscle cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.