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Article

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains.

Human molecular genetics - 15 May 2015

Ye Xuan, Sun Xiaqin, Starovoytov Valentin, Cai Qian

Abstract excerpt

Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease (AD). Mitophagy, a selective autophagy for eliminating damaged mitochondria, constitutes a key cellular pathway in mitochondrial quality control. Recent studies established that acute depolarization of mitoc...

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Identifiers

PMID: 25678552
DOI: 10.1093/hmg/ddv056
PMCID: PMC4406302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25678552-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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