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Article

Surfactant protein-D deficiency suppresses systemic inflammation and reduces atherosclerosis in ApoE knockout mice.

Cardiovascular research - 1 Aug 2017

Hirano Yuki, Choi Alex, Tsuruta Masashi, Jaw Jen Erh, Oh Yeni, Ngan David, Moritani Konosuke, Chen Yu-Wei Roy, Tam Sheena, Li Yuexin, Vasilescu Dragos M, Hogg James C, Francis Gordon, Bernatchez Pascal, Man Shu-Fan Paul, Sin Don D

Abstract excerpt

AIMS: Although surfactant protein-D (SP-D) is a pneumoprotein that is predominantly synthesized by type II epithelial cells in the lung, individuals with increased circulating levels of SP-D are at an elevated risk of mortality from ischemic heart disease. Whether SP-D contributes directly to atherosclerosis is unknown. We determined the effects of SP-D gene deletion in a mouse model of atherosclerosis. METHODS...

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Source

Identifiers

PMID: 28472244
DOI: 10.1093/cvr/cvx067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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