Screening for mismatch repair deficiency in colorectal cancer: data from three academic medical centers.

doi:10.1002/cam4.1025

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Article

Screening for mismatch repair deficiency in colorectal cancer: data from three academic medical centers.

Cancer medicine - 1 Jun 2017

O'Kane Grainne M, Ryan Éanna, McVeigh Terri P, Creavin Ben, Hyland John Mp, O'Donoghue Diarmuid P, Keegan Denise, Geraghty Robert, Flannery Delia, Nolan Carmel, Donovan Emily, Mehigan Brian J, McCormick Paul, Muldoon Cian, Farrell Michael, Shields Conor, Mulligan Niall, Kennedy Michael John, Green Andrew J, Winter Desmond C, MacMathuna Padraic, Sheahan Kieran, Gallagher David J

Abstract excerpt

Reflex immunohistochemistry (rIHC) for mismatch repair (MMR) protein expression can be used as a screening tool to detect Lynch Syndrome (LS). Increasingly the mismatch repair-deficient (dMMR) phenotype has therapeutic implications. We investigated the pattern and consequence of testing for dMMR in three Irish Cancer Centres (CCs). CRC databases were analyzed from January 2005-December 2013. CC1 performs IHC upon...

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PMID: 28470797
DOI: 10.1002/cam4.1025
PMCID: PMC5463076

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BRAF

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