Article

Challenging Standard Protocols: A New Perspective on MMR Deficiency from a Longitudinal Regional Study

2023-12-12

Abstract excerpt

The role of DNA mismatch repair (MMR) tumor testing in colon and endometrial carcinomas is well-established, yet the universal application of this testing faces challenges due to limited data on its efficacy in diverse populations. This retrospective study at a community hospital in Northern Indiana examined MMR immunohistochemistry (IHC) results across 549 cases. Our analysis found intact MMR expression in 469 ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a2d7196-383a-5207-a335-4fb75fc29ca0
DOI: 10.20944/preprints202312.0774.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Challenging Standard Protocols: A New Perspective on MMR Deficiency from a Longitudinal Regional StudyDOI 10.20944/preprints202312.0774.v1Read

Mismatch repair deficiency testing in clinical practiceSemantic proximity Read

Tumor analysis of MMR genes in Lynch-like syndrome: challenges associated to results interpretationSemantic proximity Read

Clinical Testing for Mismatch Repair in Neoplasms Using Multiple Laboratory MethodsSemantic proximity Read

Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention InitiativeSemantic proximity Read

Clinicopathologic characteristics and outcomes of endometrial Cancer patients with mismatch repair deficiency in the era of universal Lynch syndrome screening.Semantic proximity Read

Evaluation of yield and experiences of age-related molecular investigation for heritable and nonheritable causes of mismatch repair deficient colorectal cancer to identify Lynch syndrome.Semantic proximity Read

Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature ReviewSemantic proximity Read

Mismatch Repair Status Characterization in Oncologic Pathology: Taking Stock of the Real-World PossibilitiesSemantic proximity Read

A Canadian Provincial Screening Program for Lynch SyndromeSemantic proximity Read

Mutational signature profiling classifies subtypes of clinically different mismatch repair deficient tumors with a differential immunogenic response potentialSemantic proximity Read

Mismatch Repair Universal Screening of Endometrial Cancers (MUSE) in a Canadian CohortSemantic proximity Read

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndromeSemantic proximity Read