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Article

Extent of investigation and management of cases of 'unexplained' mismatch repair deficiency (u-dMMR): a UK Cancer Genetics Group consensus.

Journal of medical genetics - 20 Jun 2024

McVeigh Terri Patricia, Monahan Kevin J, Christopher Joseph, West Nick, Scott Malcolm, Murray Jennie, Hanson Helen

Abstract excerpt

BACKGROUND: Mismatch repair deficiency (dMMR) is a characteristic feature of cancers linked to Lynch syndrome. However, in most cases, it results from sporadic somatic events rather than hereditary factors. The term 'Lynch-like syndrome' (LLS) has been used to guide colorectal cancer surveillance for relatives of individuals with a dMMR tumour when somatic and germline genomic testing is uninformative. As the...

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Identifiers

PMID: 38531626
DOI: 10.1136/jmg-2024-109886
PMCID: PMC11228216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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