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Article

Impact of confounding by leukocyte composition on associations of leukocyte DNA methylation with common risk factors.

Epigenomics - 1 May 2017

Heiss Jonathan Alexander, Brenner Hermann

Abstract excerpt

AIM: One concern in epigenome-wide studies investigating leukocyte DNA methylation is that observed associations may at least partly reflect differences in leukocyte composition (LC) rather than changes in methylation. We estimated the magnitude of confounding by LC for common risk factors and diseases. MATERIALS & METHODS: Variation of LC according to sex, race, age, smoking, alcohol consumption, BMI,...

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Identifiers

PMID: 28470095
DOI: 10.2217/epi-2016-0154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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