Article
Age-related changes in the global DNA methylation profile of leukocytes are linked to nutrition but are not associated with the MTHFR C677T genotype or to functional capacities.
PloS one - 1 Jan 2012
Gomes Marcus V M, Toffoli Leandro V, Arruda Douglas W, Soldera Larissa M, Pelosi Gislaine G, Neves-Souza Rejane D, Freitas Eliane R, Castro Denilson T, Marquez Audrey S
Abstract excerpt
Global DNA methylation of peripheral blood leukocytes has been recently proposed as a potential biomarker for disease risk. However, the amplitude of the changes in DNA methylation associated with normal aging and the impacts of environmental changes on this variation are still unclear. In this context, we evaluated the association of global DNA methylation with nutritional habits, tobacco smoking, body mass...
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