Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.

doi:10.1016/j.molcel.2015.05.037

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Article

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.

Molecular cell - 6 Aug 2015

Kang Hee-Bum, Fan Jun, Lin Ruiting, Elf Shannon, Ji Quanjiang, Zhao Liang, Jin Lingtao, Seo Jae Ho, Shan Changliang, Arbiser Jack L, Cohen Cynthia, Brat Daniel, Miziorko Henry M, Kim Eunhee, Abdel-Wahab Omar, Merghoub Taha, Fröhling Stefan, Scholl Claudia, Tamayo Pablo, Barbie David A, Zhou Lu, Pollack Brian P, Fisher Kevin, Kudchadkar Ragini R, Lawson David H, Sica Gabriel, Rossi Michael, Lonial Sagar, Khoury Hanna J, Khuri Fadlo R, Lee Benjamin H, Boggon Titus J, He Chuan, Kang Sumin, Chen Jing

Abstract excerpt

Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Here we demonstrate a "synthetic lethal" interaction between oncogenic BRAF V600E and a ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL). HMGCL expression is upregulated in BRAF V600E-expressing human...

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Identifiers

PMID: 26145173
DOI: 10.1016/j.molcel.2015.05.037
PMCID: PMC4530073

Genes

BRAF
HMGCL

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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