Article
Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution.
Genomics - 1 Oct 1994
Boukaftane Y, Duncan A, Wang S, Labuda D, Robert M F, Sarrazin J, Schappert K, Mitchell G A
Abstract excerpt
Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase (mHS) is the first enzyme of ketogenesis, whereas the cytoplasmic HS isozyme (cHS) mediates an early step in cholesterol synthesis. We here report the sequence of human and mouse liver mHS cDNAs, the sequence of a HS-like cDNA from Caenorhabdi...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Gene Amplification
- Genetic Variation
- Genomic Library
- Hominidae
- Humans
- Hydroxymethylglutaryl-CoA Synthase