Article
Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.
Journal of virology - 1 Feb 2010
Kasprowicz Victoria, Kang Yu-Hoi, Lucas Michaela, Schulze zur Wiesch Julian, Kuntzen Thomas, Fleming Vicki, Nolan Brian E, Longworth Steven, Berical Andrew, Bengsch Bertram, Thimme Robert, Lewis-Ximenez Lia, Allen Todd M, Kim Arthur Y, Klenerman Paul, Lauer Georg M
Abstract excerpt
Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that...
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