Article
Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway.
Immunology - 1 Sept 2017
Huang Hongjun, Zhang Na, Xiong Qingqing, Chen Ruoyu, Zhang Chengfei, Wang Ning, Wang Li, Ren Hua, Liu Mingyao, Qian Min, Du Bing
Abstract excerpt
As the most important host defence against viral infection, interferon (IFN) stimulates hundreds of antiviral genes (ISGs) that together establish an 'antiviral state'. However, the antiviral function of most ISGs in viral infection still need further exploration. Here, we demonstrated that the expression of G-protein-coupled receptor 146 (GPR146) is highly increased by both IFN-β and IFN-γ in a signal transducer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.