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Article

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells.

PloS one - 1 Jan 2016

Sun Lin, St Leger Anthony J, Yu Cheng-Rong, He Chang, Mahdi Rashid M, Chan Chi-Chao, Wang Hongsheng, Morse Herbert C, Egwuagu Charles E

Abstract excerpt

Interferon Regulatory Factor-8 (IRF8) is constitutively expressed in monocytes and B cell lineages and plays important roles in immunity to pathogens and cancer. Although IRF8 expression is induced in activated T cells, the functional relevance of IRF8 in T cell-mediated immunity is not well understood. In this study, we used mice with targeted deletion of Irf8 in T-cells (IRF8KO) to investigate the role of IRF8...

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Identifiers

PMID: 27171004
DOI: 10.1371/journal.pone.0155420
PMCID: PMC4865128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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