Article
A genotype independent, full-genome reverse-transcription protocol for HCV genotyping and resistance testing.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2017
Walker Andreas, Bergmann Matthias, Camdereli Jennifer, Kaiser Rolf, Lübke Nadine, Timm Jörg
Abstract excerpt
BACKGROUND: HCV treatment options and cure rates have tremendously increased in the last decade. Although a pan-genotype HCV treatment has recently been approved, most DAA therapies are still genotype specific. Resistance-associated variants (RAVs) can limit the efficacy of DAA therapy and are associated with increased risk for therapy failure. With the approval of DAA regimens that recommend resistance testing...
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