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The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).

Antioxidants & redox signaling - 20 Dec 2017

Salinas Gustavo, Gao Wei, Wang Yang, Bonilla Mariana, Yu Long, Novikov Andrey, Virginio Veridiana G, Ferreira Henrique B, Vieites Marisol, Gladyshev Vadim N, Gambino Dinorah, Dai Shaodong

Abstract excerpt

AIMS: New drugs are needed to treat flatworm infections that cause severe human diseases such as schistosomiasis. The unique flatworm enzyme thioredoxin glutathione reductase (TGR), structurally different from the human enzyme, is a key drug target. Structural studies of the flatworm Echinococcus granulosus TGR, free and complexed with AuI-MPO, a novel gold inhibitor, together with inhibition assays were...

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Identifiers

PMID: 28463568
DOI: 10.1089/ars.2016.6816
PMCID: PMC5678357

Genes

MPO

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