Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials

Abstract excerpt

Urease as a potential target of antimicrobial drugs has received considerable attention given its versatile roles in microbial infection. Development of effective urease inhibitors, however, is a significant challenge due to the deeply buried active site and highly specific substrate of a bacterial urease. Conventionally, urease inhibitors are designed by either targeting the active site or mimicking substrate of...

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