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Article

Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).

The Biochemical journal - 15 Jan 2010

Patel Shreenal, Hussain Syeed, Harris Richard, Sardiwal Sunita, Kelly John M, Wilkinson Shane R, Driscoll Paul C, Djordjevic Snezana

Abstract excerpt

Current drug therapies against Trypanosoma cruzi, the causative agent of Chagas disease, have limited effectiveness and are highly toxic. T. cruzi-specific metabolic pathways that utilize trypanothione for the reduction of peroxides are being explored as potential novel therapeutic targets. In the present study we solved the X-ray crystal structure of one of the T. cruzi enzymes involved in peroxide reduction,...

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Identifiers

PMID: 19886864
DOI: 10.1042/BJ20091167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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