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Article

Role of the glutaredoxin domain and FAD in the stabilization of thioredoxin glutathione reductase.

Archives of biochemistry and biophysics - 15 Oct 2018

Kalita Parismita, Shukla Harish, Gadhave Kundlik, Giri Rajanish, Tripathi Timir

Abstract excerpt

Thioredoxin glutathione reductase (TGRsec) is a multi-domain flavoprotein that plays a principal role in redox homeostasis maintenance. We have previously demonstrated the role of selenocysteine in maintaining TGRsec structure-function, but the role of the glutaredoxin (Grx) domain and FAD is still unclear. In the present study, the urea-induced unfolding of recombinant Fasciola gigantica TGRsec (FgTGRsec) and...

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Identifiers

PMID: 30205085
DOI: 10.1016/j.abb.2018.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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