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Article

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.

Journal of structural biology - 1 May 2016

Parsonage Derek, Sheng Fang, Hirata Ken, Debnath Anjan, McKerrow James H, Reed Sharon L, Abagyan Ruben, Poole Leslie B, Podust Larissa M

Abstract excerpt

The anti-arthritic gold-containing drug Auranofin is lethal to the protozoan intestinal parasite Entamoeba histolytica, the causative agent of human amebiasis, in both culture and animal models of the disease. A putative mechanism of Auranofin action proposes that monovalent gold, Au(I), released from the drug, can bind to the redox-active dithiol group of thioredoxin reductase (TrxR). Au(I) binding in the active...

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Identifiers

PMID: 26876147
DOI: 10.1016/j.jsb.2016.02.015
PMCID: PMC5003402

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