Article
Increased familial risk of the psychotic phenotype of Alzheimer disease.
Neurology - 26 Mar 2002
Sweet R A, Nimgaonkar V L, Devlin B, Lopez O L, DeKosky S T
Abstract excerpt
BACKGROUND: Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors. OBJECTIVE: To determine if AD+P aggregates within families. METHODS: Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic...
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