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Article

Tumorigenesis promotes Mdm4-S overexpression.

Oncotarget - 18 Apr 2017

Pant Vinod, Larsson Connie A, Aryal Neeraj, Xiong Shunbin, You M James, Quintas-Cardama Alfonso, Lozano Guillermina

Abstract excerpt

Disruption of the p53 tumor suppressor pathway is a primary cause of tumorigenesis. In addition to mutation of the p53 gene itself, overexpression of major negative regulators of p53, MDM2 and MDM4, also act as drivers for tumor development. Recent studies suggest that expression of splice variants of Mdm2 and Mdm4 may be similarly involved in tumor development. In particular, multiple studies show that...

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Share to Cell Cycle Proteins
Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Nuclear Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 28460439
DOI: 10.18632/oncotarget.15552
PMCID: PMC5432220

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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