Article
Streptococcus pneumoniae-induced ototoxicity in organ of Corti explant cultures.
Hearing research - 1 Jul 2017
Perny Michael, Solyga Magdalena, Grandgirard Denis, Roccio Marta, Leib Stephen L, Senn Pascal
Abstract excerpt
Hearing loss remains the most common long-term complication of pneumococcal meningitis (PM) reported in up to 30% of survivors. Streptococcus pneumoniae have been shown to possess different ototoxic properties. Here we present a novel ex vivo experimental setup to examine in detail the pattern of hair cell loss upon exposure to different S. pneumoniae strains, therefore recapitulating pathogen derived aspects of...
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