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Article

Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.

Behavioural brain research - 30 Jun 2017

Salminen Lauren E, Schofield Peter R, Pierce Kerrie D, Bruce Steven E, Griffin Michael G, Tate David F, Cabeen Ryan P, Laidlaw David H, Conturo Thomas E, Bolzenius Jacob D, Paul Robert H

Abstract excerpt

Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 (SOD2) and catalase (CAT) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic...

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Identifiers

PMID: 28457881
DOI: 10.1016/j.bbr.2017.04.041
PMCID: PMC5515475

Genes

SOD2
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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