Article
Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholics.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2010
Srivastava Vibhuti, Buzas Beata, Momenan Reza, Oroszi Gabor, Pulay Attila J, Enoch Mary-Anne, Hommer Daniel W, Goldman David
Abstract excerpt
Chronic alcoholism leads to gray matter shrinkage and induces the formation of superoxide anions (O(2)(-)) that can cause neuronal cell death. The mitochondrial superoxide dismutase 2 (SOD2) enzyme is critical in the metabolism of superoxide. An Ala16Val polymorphism putatively affects SOD2 enzyme activity in vivo. Brain volumes of 76 treatment-seeking alcohol-dependent individuals were measured with a 1.5T MRI....
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