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Article

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene.

Atherosclerosis - 1 Jun 2017

Fairoozy Roaa Hani, Cooper Jackie, White Jon, Giambartolomei Claudia, Folkersen Lasse, Wannamethee S Goya, Jefferis Barbara J, Whincup Peter, Ben-Shlomo Yoav, Kumari Meena, Kivimaki Mika, Wong Andrew, Hardy Rebecca, Kuh Diana, Gaunt Tom R, Casas J P, McLachlan Stela, Price Jackie F, Hingorani Aroon, Franco-Cereceda Anders, Grewal Thomas, Kalea Anastasia Z, Humphries Steve E

Abstract excerpt

BACKGROUND AND AIMS: Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein cholesterol-receptors (LDL-R) and thereby regulate low-density lipoprotein cholesterol (LDL-C) levels. Here we identify variants in ANXA2 influencing LDL-C levels and...

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Source

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Identifiers

PMID: 28456096
DOI: 10.1016/j.atherosclerosis.2017.04.010
PMCID: PMC5446264

Genes

ANXA2
PCSK9

Variants

rs17845226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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