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Article

Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis.

Nature genetics - 1 Sept 2008

Hofmann Sylvia, Franke Andre, Fischer Annegret, Jacobs Gunnar, Nothnagel Michael, Gaede Karoline I, Schürmann Manfred, Müller-Quernheim Joachim, Krawczak Michael, Rosenstiel Philip, Schreiber Stefan

Abstract excerpt

Sarcoidosis is a complex chronic inflammatory disorder with predominant manifestation in the lung. In the first genome-wide association study (> 440,000 SNPs) of this disease, comprising 499 German individuals with sarcoidosis and 490 controls, we detected a series of genetic associations. The strongest association signal maps to the ANXA11 (annexin A11) gene on chromosome 10q22.3. Validation in an independent...

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Source

Identifiers

PMID: 19165924
DOI: 10.1038/ng.198

Genes

ANXA11

Variants

rs1049550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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