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Article

PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter

26 Apr 2017

Abstract excerpt

The Epstein Barr virus (EBV) genome persists in infected host cells as a chromatinized episome and is subject to chromatin-mediated regulation. Binding of the host insulator protein CTCF to the EBV genome has an established role in maintaining viral latency type, and in other herpesviruses, loss of CTCF binding at specific regions correlates with viral reactivation. Here, we demonstrate that binding of PARP1, an...

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PMID: 28456021
DOI: 10.1016/j.virol.2017.04.006

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