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Article

Epigenetic modification of the Epstein-Barr virus BZLF1 promoter regulates viral reactivation from latency

1 Jan 2013

Abstract excerpt

The Epstein-Barr virus (EBV) is an oncogenic human gamma-herpesvirus that predominantly establishes latent infection in B lymphocytes. Viral genomes exist as extrachromosomal episomes with a nucleosomal structure. Maintenance of virus latency or execution of reactivation is controlled by the expression of BZLF1, a viral immediate-early gene product, tightly controlled at the transcriptional level. In this...

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Identifiers

PMID: 23577022
DOI: 10.3389/fgene.2013.00053

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