Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension.

doi:10.1016/j.tube.2020.101899

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Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2020

Ofori-Anyinam Boatema, Riley Abi Janet, Jobarteh Tijan, Gitteh Ensa, Sarr Binta, Faal-Jawara Tutty Isatou, Rigouts Leen, Senghore Madikay, Kehinde Aderemi, Onyejepu Nneka, Antonio Martin, de Jong Bouke C, Gehre Florian, Meehan Conor J

Abstract excerpt

The geographically restricted Mycobacterium africanum lineages (MAF) are primarily found in West Africa, where they account for a significant proportion of tuberculosis. Despite this phenomenon, little is known about the co-evolution of these ancient lineages with West Africans. MAF and M. tuberculosis sensu stricto lineages (MTB) differ in their clinical, in vitro and in vivo characteristics for reasons not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32090860
DOI: 10.1016/j.tube.2020.101899
PMCID: PMC7049902

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