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Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms.

Tuberculosis (Edinburgh, Scotland) - 1 May 2014

Jiang Yi, Wan Li, Zhang Zhijian, Liu Haican, Pang Hui, Zhang Wen, Zhao Xiuqin, Wang Haiyin, Li Guilian, Chen Chen, Kan Biao, Wan Kanglin

Abstract excerpt

Host immune pressure and associated parasite immune evasion are key features of host-pathogen co-evolution. A previous study showed that human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved and thus it was deduced that M. tuberculosis lacks antigenic variation and immune evasion. Here, we selected 162 clinical M. tuberculosis complex (MTBC) isolates from China, amplified gene...

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Identifiers

PMID: 24674998
DOI: 10.1016/j.tube.2014.02.002

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