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Article

Genetic diversity of antigens Rv2945c and Rv0309 in Mycobacterium tuberculosis strains may reflect ongoing immune evasion.

FEMS microbiology letters - 1 Oct 2013

Jiang Yi, Dou Xiangfeng, Zhang Wen, Liu Haican, Zhao Xiuqin, Wang Haiyin, Lian Lulu, Yu Qin, Zhang Jingrui, Li Guilian, Chen Chen, Wan Kanglin

Abstract excerpt

Host immune pressure and associated immune evasion of pathogenic bacteria are key features of host-pathogen co-evolution. A previous study showed that human T-cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved and thus it was deduced that M. tuberculosis lacks antigenic variation and immune evasion. Here, we selected 173 clinical M. tuberculosis complex (MTBC) isolates from China,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23889607
DOI: 10.1111/1574-6968.12222

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