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Article

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.

Human molecular genetics - 1 Aug 2017

Beel Sander, Moisse Matthieu, Damme Markus, De Muynck Louis, Robberecht Wim, Van Den Bosch Ludo, Saftig Paul, Van Damme Philip

Abstract excerpt

Loss of function mutations in progranulin (GRN) cause frontotemporal dementia, but how GRN haploinsufficiency causes neuronal dysfunction remains unclear. We previously showed that GRN is neurotrophic in vitro. Here, we used an in vivo axonal outgrowth system and observed a delayed recovery in GRN-/- mice after facial nerve injury. This deficit was rescued by reintroduction of human GRN and relied on its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

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Source

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Identifiers

PMID: 28453791
DOI: 10.1093/hmg/ddx162
PMCID: PMC5886064

Genes

GRN
CTSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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