Article
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
Human molecular genetics - 15 Jul 2017
Blanca Ramírez Marian, Lara Ordóñez Antonio Jesús, Fdez Elena, Madero-Pérez Jesús, Gonnelli Adriano, Drouyer Matthieu, Chartier-Harlin Marie-Christine, Taymans Jean-Marc, Bubacco Luigi, Greggio Elisa, Hilfiker Sabine
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the most common cause of familial Parkinson's disease (PD), and sequence variants modify risk for sporadic PD. Previous studies indicate that LRRK2 interacts with microtubules (MTs) and alters MT-mediated vesicular transport processes. However, the molecular determinants within LRRK2 required for such interactions have remained unknown. Here, we report...
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