Article
The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma.
Genome medicine - 7 Sept 2021
Chen Zhang-Hua, Yan Shu-Mei, Chen Xi-Xi, Zhang Qi, Liu Shang-Xin, Liu Yang, Luo Yi-Ling, Zhang Chao, Xu Miao, Zhao Yi-Fan, Huang Li-Yun, Liu Bin-Liu, Xia Tian-Liang, Xu Da-Zhi, Liang Yao, Chen Yong-Ming, Wang Wei, Yuan Shu-Qiang, Zhang Hui-Zhong, Yun Jing-Ping, Zhai Wei-Wei, Zeng Mu-Sheng, Bai Fan, Zhong Qian
Abstract excerpt
BACKGROUND: Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) present unique molecular signatures, but the tumorigenesis of EBVaGCs and the role EBV plays during this process remain poorly understood. METHODS: We applied whole-exome sequencing, EBV genome sequencing, and whole-genome bisulfite sequencing to multiple samples (n = 123) derived from the same patients (n = 25), which covered saliva...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.