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[Landscape of KRAS, BRAF, and PIK3CA Mutations and Clinical Features of EBV-Associated and Microsatellite Unstable Gastric Cancer].

Molekuliarnaia biologiia - 1 Jan 2000

Danishevich A M, Pospehova N I, Stroganova A M, Golovina D A, Nikulin M P, Kalinin A E, Nikolaev S E, Stilidi I S, Lyubchenko L N

Abstract excerpt

Personalization of gastric cancer (GC) treatment is an urgent problem because of the clinical heterogeneity and aggressive course of the disease. Four GC subtypes were isolated based on molecular characteristics by The Cancer Genome Atlas researchers in 2014: Epstein-Barr virus positive (EBV^(+)), microsatellite unstable (MSI), chromosomally unstable (CIN), and genomically stable (GS). There is no unified method...

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PMID: 36976740
DOI: 10.31857/S0026898423010044

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