Article

Deep Sequencing of The HIV-1 Polymerase Gene For Characterisation of Cytotoxic T-Lymphocyte Epitopes During Early And Chronic Disease Stages

2021-11-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Despite multiple attempts, there is still no effective HIV-1 vaccine available. The HIV-1 polymerase (<italic>pol</italic>) gene is highly conserved and encodes cytotoxic T-lymphocyte (CTL) epitopes. The aim of the study was to characterise HIV-1 Pol CTL epitopes in mostly sample pairs obtained during early and chronic stages of infection.<bold>Methods</bold>: I...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4e88acf-a562-5965-9614-bae832f2aead
DOI: 10.21203/rs.3.rs-842193/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep Sequencing of The HIV-1 Polymerase Gene For Characterisation of Cytotoxic T-Lymphocyte Epitopes During Early And Chronic Disease StagesDOI 10.21203/rs.3.rs-842193/v3Read

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.Semantic proximity Read

Computational comparison of availability in CTL/gag epitopes among patients with acute and chronic HIV-1 infection.Semantic proximity Read

Evaluation of CD8+ T cell responses towards conserved HIV-1 epitopes in naturally infected and vaccinated individualsSemantic proximity Read

Full-coverage native RNA sequencing of HIV-1 virusesSemantic proximity Read

The role of subtyping methodologies in HIV surveillance and vaccine development: a systematic review and meta-analysis.Semantic proximity Read

Characterization of Hepatitis Delta Virus (Sub)genotypes Identifies Conserved Functional Domains and Cytotoxic T Lymphocytes Epitopes Amidst Genetic VariabilitySemantic proximity Read

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infectionSemantic proximity Read

Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection.Semantic proximity Read

Human immunodeficiency virus mutations during the first month of infection are preferentially found in known cytotoxic T-lymphocyte epitopes.Semantic proximity Read

Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in patients receiving antiretroviral therapy: a study from Provir/Latitude45 projectSemantic proximity Read

Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation.Semantic proximity Read

Next-Generation Sequencing Reveals a High Frequency of HIV-1 Minority Variants and an Expanded Drug Resistance Profile among Individuals on First-Line ART.Semantic proximity Read