Article

HPV T-cell epitope landscape: systematic mapping of distribution, conservation, and HLA promiscuity towards rational vaccine design

2025-11-06

Abstract excerpt

<h4>Background</h4> Human papillomavirus (HPV) drives both malignant and benign tumors, yet the current prophylactic vaccines remain type-restricted and are not optimized for T-cell induction. Evidence shows that T-cells can both block and clear viral infections, supporting T-cell-based vaccines. We compile a comprehensive list of T-cell epitopes, analyze specificity and immunodominance, and perform in silico an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee44e78a-0d82-5e4e-810b-81e0b6944555
DOI: 10.1101/2025.11.03.25339381

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HPV T-cell epitope landscape: systematic mapping of distribution, conservation, and HLA promiscuity towards rational vaccine designDOI 10.1101/2025.11.03.25339381Read

HPV16-E7 Protein T Cell Epitope Prediction and Global Therapeutic Peptide Vaccine Design Based on Human Leukocyte Antigen Frequency: An In-Silico StudySemantic proximity Read

HPV-16 E6 and E7 protein T cell epitopes prediction analysis based on distributions of HLA-A loci across populations: An in silico approachSemantic proximity Read

Designing and immunomolecular analysis of a new broad-spectrum multiepitope vaccine against divergent human papillomavirus typesSemantic proximity Read

In silico/In vivo analysis of high-risk papillomavirus L1 and L2 conserved sequences for development of cross-subtype prophylactic vaccineSemantic proximity Read

Genetic Variability and Conserved T-Cell Epitope Prediction of the HPV16 E1 Protein in Cervix Samples from Peru.Semantic proximity Read

Identification of Immunodominant T-lymphocyte Epitope Peptides in HPV 1, 2 and 3 L1 Protein for Novel Cutaneous Wart VaccineSemantic proximity Read

A comprehensive in silico analysis for identification of therapeutic epitopes in HPV16, 18, 31 and 45 oncoproteinsSemantic proximity Read

Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer.Semantic proximity Read

Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapySemantic proximity Read

Impaired HPV driven CD8 T cells recognition and Immune suppression in HPV-Induced Cervical CancerSemantic proximity Read

Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccinesSemantic proximity Read

Whole-Proteome Screening and Multi-Modal Profiling of Antigen-Specific CD4+ T Cells at Single-Cell ResolutionSemantic proximity Read