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Article

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation

1 Feb 2011

Abstract excerpt

AIMS: Human congenital heart disease linked to mutations in the homeobox transcription factor, NKX2-5, is characterized by cardiac anomalies, including atrial and ventricular septal defects as well as conduction and occasional defects in contractility. In the mouse, homozygous germline deletion of Nkx2-5 gene results in death around E10.5. It is, however, not established whether Nkx2-5 is necessary for cardiac...

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PMID: 21285290
DOI: 10.1093/cvr/cvr037

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