MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males.

doi:10.18632/oncotarget.15587

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MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males.

Oncotarget - 11 Apr 2017

Chen Junyu, Liu Wanlin, Cao Yuju, Zhang Xiyang, Guo Yongchang, Zhu Yong, Li Jian, Du Jieli, Jin Tianbo, Wang Guoqiang, Wang Jianzhong

Abstract excerpt

Our study investigated the association between MMP-3 and MMP-8 single-nucleotide polymorphisms (SNPs) and alcohol-induced osteonecrosis of the femoral head (ONFH) in 695 Chinese males (299 cases and 396 control subjects). The minor allele of MMP-3 rs650108 was associated with a 0.78-fold decrease in alcohol-induced ONFH risk in the allelic model (95% CI = 0.63-0.97, P = 0.026). In the genetic model adjusted for...

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PMID: 28445942
DOI: 10.18632/oncotarget.15587
PMCID: PMC5421920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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