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Article

Genomic diversification, adaptive convergence, and regulatory rewiring in aging Escherichia coli colonies.

BMC microbiology - 31 Mar 2026

Saint-Ruf Claude, Launay Adrien, Tenaillon Olivier, Matic Ivan

Abstract excerpt

BACKGROUND: Bacterial colonies are dynamic evolutionary microenvironments where spatial heterogeneity and nutrient gradients generate diverse ecological niches. Understanding how such structured environments drive genetic and functional diversification, including the emergence of clinically relevant traits such as antibiotic resistance, remains a major challenge. METHODS: To dissect adaptive strategies in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41917834
DOI: 10.1186/s12866-026-04983-z
PMCID: PMC13162491

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