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Activation of SREBP-1c alters lipogenesis and promotes tumor growth and metastasis in gastric cancer

25 May 2020

Abstract excerpt

PURPOSE: Aggressively growing tumors are characterized by significant variations in metabolites, including lipids, and can involve the elevated synthesis ofde novo fatty acids. METHODS: Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)-based metabolomics and lipidomics were performed to compare human gastric cancer tissues and adjacent normal tissues from clinical patients. A series of...

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PMID: 32464305
DOI: 10.1016/j.biopha.2020.110274

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