Article
PLCB4 copy gain and PLCß4 overexpression in primary gastrointestinal stromal tumors: Integrative characterization of a lipid-catabolizing enzyme associated with worse disease-free survival.
Oncotarget - 21 Mar 2017
Li Chien-Feng, Liu Ting-Ting, Chuang I-Chieh, Chen Yen-Yang, Fang Fu-Min, Chan Ti-Chun, Li Wan-Shan, Huang Hsuan-Ying
Abstract excerpt
To explore the implications of lipid catabolism-associated genes in gastrointestinal stromal tumors, we reappraised transcriptomic and genomic datasets and identified copy-gained and differentially upregulated PLCB4 gene associated with tumor progression. On full sections, PLCB4 mRNA abundance and PLCß4 immunoexpression were validated in 70 cases. On tissue microarrays, PLCB4 gene copies and PLCß4...
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